Factorial analysis showing regions of statistical significant differences in functional brain activation.

Shown is the main effect in non-exercised rats of Lesion and the Lesion×Walk interaction (Groups: Lesion/Walk/No-ET, n = 9; Sham/Walk/No-ET, n = 10; Lesion/Rest/No-ET, n = 10; Sham/Rest/No-ET, n = 9). Also shown is the main effect in lesioned rats of Exercise and the Exercise×Walk interaction (Lesion/Walk/No-ET, n = 9; Lesion/Rest/No-ET, n = 10; Lesion/Walk/ET, n = 11; Lesion/Rest/ET, n = 12). Significance (*) for all entries is shown at the voxel level (P<0.05) with a minimum extent threshold of 100 contiguous voxels. Abbreviations are those from the Paxinos and Watson rat atlas [39]: 5 (trigeminal n., motor, sensory), aca (anterior commissures), AHi (amygdalo-hippocampal area); APir (amygdalo-piriform transition area); BL (basolateral amygdala), Ce (central amygdalar n.), Cg (cingulate cortex), CM (central medial thalamic n.), CPu (striatum: anterior, ant-CPu; dorsal, d-CPu; ventral, v-CPu), d-HPC (dorsal hippocampus), DTg/LDTg (dorsal/laterodorsal tegmental n.), Ent (entorhinal cortex), GPe (external globus pallidus), GPi (internal globus pallidus/entopeduncular n.), Hb (habenula), I (insular cortex), IL (infralimbic cortex), La (lateral amygdala), LO (lateral orbital cortex), LP (lateral posterior thalamic n.), LS (lateral septum), M1, M2 (primary, secondary motor cortex), Me (medial amygdala), MS (medial septum), Pir (piriform cortex), PrL (prelimbic cortex), PtA (parietal association cortex), PTg (pedunculopontine tegmental n.), RPC (red n.), RS (retrosplenial cortex), S1DZ, S1FL, S1J, S1Tr, S1ULp, (primary somatosensory cortex: dysgranular, forelimb, jaw, trunk, lip), S2 (secondary somatosensory cortex), SC (superior colliculus), vermis (2nd, 3rd cerebellar simple lobule), V1, V2 (primary, secondary visual cortex), v-HPC (ventral hippocampus), VL (ventral lateral thalamic n.), VM (ventromedial thalamic n.), VMH (ventromedial hypothalamus), VPL/VPM (ventral posterolateral, ventral posteromedial thalamic nuclei), VP (ventral pallidum), VS (ventral subiculum), ZI (zona inserta).