In vivo gene expression analysis of C elegans in response to rifampicin

We have discovered rifampicin as a glycation inhibitor, which increases life span in C elegans. In order to understand the mechanism of rifampicin action, microarray analysis was performed to study the changes in gene expression brought about by the drug. Gene expression profile of wild type N2 worms treated with rifampicin w.r.t to control (DMSO treated) worms.Total RNA was isolated from worms on 8th day of adulthoodin presence of FuDr. Two independent biological replicates for each treatment were analyzed.