Reference Profiles of ExRNAs in Normal Human Pregnancy

In this study, we did a comprehensive exRNA profiling of plasma and serum specimens from healthy pregnant women, sampled at different gestational time points, and including subjects with diverse geographical and ethnic backgrounds. This study also contains samples from male and female healthy donors to provide a baseline. The aim of this study is to identify miRNAs that can predict the gestation age and to build a miRNA profile across gestation using small RNA-seq data. ]]>
Inclusion criteria for the pregnant group: 18-45 years of age Within the first 14 weeks of pregnancy Singleton pregnancy Healthy women with no previous history of poor obstetrical outcome, chronic hypertension or renal disease Agrees to allow for the placenta to be sent to Pathology for evaluation Exclusion criteria for the pregnant group: Known maternal or fetal chromosomal abnormalities Major fetal anomaly Patient desires to keep the placenta or collect cord blood for personal use Institutionalization for psychiatric disorder, mental retardation, or criminal activity Inability to provide informed consent Inclusion criteria for the non-pregnant group: Non-pregnant women 18-45 years of age Healthy women with no previous history of chronic hypertension or renal disease Exclusion criteria for the non-pregnant group:Institutionalization for psychiatric disorder, mental retardation, or criminal activity Inability to provide informed consent]]>