Bulk transcriptome sequencing (bulkRNA-seq) of human cerebrospinal fluid (CSF) cells in the bacterial meningitis (BM) of children

Purpose: Profiling the bulk transcriptomes of CSF cells in sepsis-developed BM progression. Methods: The total RNA of CSF cells from BM patients were extracted, and constructed into cDNA library. Raw data of mRNA profiles were sequenced by paired-end strategy. Gene-counts were generated through handling sequencing data with the combined workflow of UMI-tools, STAR, Subread package and Samtools. Results: Successfully acquirng multiple bulk-transcriptomic profiles of CSF cells from BM patients in different sepsis conditions. Overall design: mRNA profiles of CSF cells in different onset conditions during BM progression. *** For consistency with the publication (PMID 36119025), new data have been added (GSM8118556-GSM8118567, February 2024). The original data (GSM4974411-GSM4974421, December 2020) are not discussed in the above publication and have been removed. ***