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A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia [bulk RNA-seq]

NIAID Data Ecosystem2026-03-14 收录

干细胞自我更新机制

白血病转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP321417 数据链接链接失效反馈

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资源简介：

we uncover a key transcriptional network involving hundreds of genes that is required for HSC self-renewal. Overall design: MECOM impact on the hematopoietic stem cells

应用场景：

创建时间：

2022-11-24

干细胞自我更新机制

FGF信号通路调控

By using the AG1478 inhibition model and RNA-seq analysis, we discovered the importance of EGFR in self-renewal and pluripotency through regulating cell cycle and the expression of pluripotency factor

NIAID Data Ecosystem80

The effects of expression of mutant ASXL1 and HHEX on hematopoietic cells. The effects of expression of mutant ASXL1 and HHEX on hematopoietic cells

白血病转录调控

造血细胞基因表达

To identify target genes of mutant ASXL1 (ASXL1-MT) and HHEX in hematopoietic cells, we performed RNA-seq using RUNX1-ETO expressing cord blood cells transduced with vector or ASXL1-MT together with v

NIAID Data Ecosystem60

ChIP-chip enriched genes.

ChIP-chip基因富集分析

白血病转录调控

Displayed are 8 ChIP-chip samples with the ERG mRNA expression measured by quantitative real-time PCR as well as the number of significantly enriched single genes, identified by ChIP-chip using BRB Ar

NIAID Data Ecosystem30

Effective FTO inhibitors with potent anti-tumor efficacy suppress cancer stem/initiating cell self-renewal and overcome immune evasion. Effective FTO inhibitors with potent anti-tumor efficacy suppress cancer stem/initiating cell self-renewal and overcome immune evasion

FTO基因调控

干细胞自我更新机制

We conducted RNA sequencing with poly A RNA isolated from NOMO-1 cells upon shRNA induced FTO knockdown and small molecules (CS1 and CS2) mediated FTO inhibition . Overall design: The NOMO-1 cells wer

NIAID Data Ecosystem60

Brd4 and CEBPB binding profiles with or without BET inhibitor JQ1 in human leukemia OCI-AML3 cells

白血病转录调控

BET抑制剂

Brd4 is the best characterized member of the bromo- and extra-terminal (BET) domain family of proteins and has been widely studied in tumor-associated transcriptional programs. Here we show that activ

NIAID Data Ecosystem30

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia [bulk RNA-seq]

资源简介：

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