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Expression data from Saccharomyces cerevisiae strains deleted for the THSC/TREX-2 subunits Thp1, Sac3 and Sus1

Alliance of Genome Resources2026-08-01 收录

转录-复制冲突

基因组不稳定性

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https://www.yeastgenome.org/dataset/GSE56702 数据链接链接失效反馈

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Transcription is a major obstacle for replication fork progression and a cause of genome instability

应用场景：

白血病分子机制

基因组不稳定性

Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and features of chrom

NIAID Data Ecosystem60

Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA

复制叉保护机制

基因组不稳定性

Degradation and collapse of stalled replication forks are main sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse are not well understood. Here

NIAID Data Ecosystem40

Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations

跨代表观遗传

基因组不稳定性

A variety of environmental factors have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. This involves the germline transmission of epigenetic inf

Taylor & Francis Group2016-01-20 更新10

Data_Sheet_1_Genome Instability-Derived Genes Are Novel Prognostic Biomarkers for Triple-Negative Breast Cancer.docx

三阴性乳腺癌

基因组不稳定性

BackgroundTriple-negative breast cancer (TNBC) is an aggressive disease. Recent studies have identified genome instability-derived genes for patient outcomes. However, most of the studies mainly focus

NIAID Data Ecosystem40

Hybrid_Decay_RNA-seq. Zea mays

植物杂交衰退

基因组不稳定性

We describe a phenomenon in maize and its nearest wild relative, teosinte, by which backcross progeny of a specific teosinte and maize exhibit a sickly whole-plant phenotype involving changes in morph

NIAID Data Ecosystem20

Expression data from Saccharomyces cerevisiae strains deleted for the THSC/TREX-2 subunits Thp1, Sac3 and Sus1

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