Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.omicsdi.org/dataset/ega/EGAS00001003821
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资源简介：
High-grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT) epithelium, but advanced stages are mostly found outside the FT. We used ex-vivo cultures of HGSOC and knock-out of tumor suppressors in FT organoids to study changes in epithelial cells and niche requirements for normal and transformed FT cells. We found that transformed cells require BMP signaling and are growth arrested in Wnt rich medium.EGA study EGAS00001003821
创建时间：
2020-07-16
