We transduced lentivirus harboring vectors expressingGFP-FTO or GFP-control fusion proteins into human multiple myeloma cell line RPMI8226 and then seclected individual stable clones under selection o
Purpose: In this study we compared bone marrow-derived mesenchymal stem cells (MSC) of 6 Multiple Myeloma patients (MM-MSC) with MSC of 5 control donors with other (non) malignant diseases (CTR-MSC) t
The ubiquitin proteasome system plays an important role in the pathophysiology of Multiple Myeloma, highlighted by the unique success of proteasome inhibitors in this malignancy. Using topic-defined m
The overexpression of the histone methyltransferase NSD2 (MMSET) in multiple myeloma (MM) patients plays a significant role in the development of this specific subtype of disease. Through the expansio
