Clinical Interpretation of Variants in Cancer

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. Realizing precision medicine will require information to be centralized, debated and interpreted for application in the clinic. CIViC is an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer. Our goal is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations.CIViC是一款由专家众包构建的癌症变异临床解读（Clinical Interpretation of Variants in Cancer）知识库，可系统阐释各类遗传性与体细胞癌变异在治疗、预后、诊断及易感层面的临床相关性。实现精准医疗需将相关信息进行集中整合、研讨与解读，以适配临床应用需求。CIViC是一款开放获取、开源且由社区驱动的癌症变异临床解读网络资源。其核心目标是搭建学术交流平台，推动知识传播并积极研讨癌症基因组变异的临床意义，以此助力精准医疗的落地发展。

搜集汇总

背景与挑战

背景概述

CIViC是一个开放获取、开源且社区驱动的癌症变异临床解释知识库，通过专家众包方式集中、讨论和解释遗传与体细胞变异的治疗、预后、诊断和易感性意义。它旨在支持精准医疗，提供丰富的知识库模块、统计数据、持续更新功能（如支持区域、分子特征等）以及资源整合（如API、AI集成），以促进临床应用的协作与教育。