Comparison time-to-solve the SSP.

FTM performance and each variant of reduction including conductance replacement (K1 representative of K2, Ka and h), individual ion channel submodel SS approximations as noted, and the full RTM with all reduced items presented. Solutions of the single cell SSP performed in OpenCOR using CVODE with maximum dt = 0.1, tolerances (relative/absolute) at 1e−7, with n = 10 trials each on a macbook pro laptop. Solutions of 2D and 3D tissue SSP trials performed using CHASTE with CVODE (dtmax = 0.1 with default settings) on a single-thread of Intel Xeon 6254 CPU with n = 10 trials. Average time to solve (μ) and standard deviation for the set of trials (σ) provided as noted. Percent improvement calculated as change relative to results with FTM, i.e., abs(tFTM − tRTM)/tFTM.