Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns.

Data for the manuscript entitled: Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns.This dataset accompanies a study demonstrating that human and rat podocytes express enzymatically active neutrophil serine proteases (NSPs), including neutrophil elastase, proteinase 3, and cathepsin G, as well as their endogenous inhibitors, serpins. We show that the expression and activity of these proteases are regulated by inflammatory molecular patterns. Notably, podocytes release NSPs in extracellular vesicles and secrete mitochondrial DNA in response to inflammatory stimuli without compromising cell viability. We also identified, for the first time, the expression and redistribution of myeloperoxidase in podocytes upon stimulation.These data were used to create Figures 2-10. All data for Figures have been included in the file Figure 2–10.