Permanent Microporosity and Enantioselective Sorption in a Chiral Open Framework

A homochiral microporous material is presented. The phase has 47% permanently porous void
volume and is shown to have >1 nm diameter pores with three-dimensional channels using probe molecule
sorption. Enantioselective guest sorption is strongly dependent on guest size. The homochiral microporous
phase was identified by reactive selection from a first-generation chiral but nonporous framework. Chiral
permanent porosity is established by directional noncovalent interactions between framework-forming and
nonframework forming components of the stable second-generation material, which become stronger upon
loss of the guests from the pore system.