Dietary Fiber Intake, Gut Microbiota, and Systemic Inflammation: A Multi-Cohort Analysis on Biological Aging in NHANES and FGID Patients

This study investigates the role of gut microbiota in modulating the effects of dietary fiber intake on biological aging. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) and patients with functional gastrointestinal disorders (FGID), the research explores how dietary fiber influences systemic inflammation and aging through changes in gut microbial composition. Specifically, it identifies key bacterial genera, such as Enterococcus, that mediate the relationship between fiber intake, inflammation, and aging. The findings aim to provide a deeper understanding of how gut microbiota can influence aging processes and highlight the potential for microbiome-targeted interventions in promoting healthy aging.