FGFR1 kinase domain with a covalent inhibitor 9p

FGFR1 kinase domain with a covalent inhibitor 9p Descriptor: Fibroblast growth factor receptor 1, SULFATE ION, ~{N}-[1-methyl-3-[2-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-5~{H}-pyrrolo[2,3-b]pyrazin-7-yl]indol-6-yl]propanamide Authors: Chen, X.J, Chen, Y.H. Deposit date: 2025-04-14 Release date: 2025-09-24 Last modified: 2025-10-08 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1 H -indole-3-yl)-5 H -pyrrolo[2,3- b ]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance. J.Med.Chem., 68, 2025