National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)

NIAGADS is an NIH controlled-access data repository that collaborates with researchers around the world to facilitate data access and sharing for genomic and associated omics data related to Alzheimer's Disease (AD), Alzheimer's Disease Related Dementias (ADRD), as well as healthy aging. Serving as the data coordinating center for the Alzheimer's Disease Sequencing Project (ADSP), NIAGADS hosts all ADSP-generated whole-exome, whole-genome and associated phenotypes. Other data types hosted by NIAGADS include genotype SNP arrays, functional omics, fluid biomarkers, aggregated imaging data (such as volumetric data for brain regions of interest), and summary statistics. In adherence with NIH security best practices and genome data sharing policies, NIAGADS supports data access requests through review by an NIH-appointed and registered Data Access Committee. Data stored within NIAGADS cannot be requested via dbGaP. Data requests must go through the NIAGADS Data Sharing Service (DSS) via the following NIAGADS url: https://dss.niagads.org/. Questions related to the request of data should be directed to the NIAGADS admin team at: [e-mail]. DSS is a FISMA certified platform built by a team of data scientists at the University of Pennsylvania to support the request and access of AD/ADRD data by qualified researchers internationally. Questions related to the use of data hosted in the DSS should be directed to the Portal admin team at: [e-mail]. ]]>
The studies in the NIAGADS DSS focus on Alzheimer's disease, related dementias, healthy aging and other neurodegenerative diseases from a variety of experimental and cohort selection perspectives. Details of each study including inclusion/exclusion criteria can be found on each study page within the study directory page, Studies Archive-DSS NIAGADS: https://dss.niagads.org/studies/.]]>
NIAGADS was established as a cooperative agreement between the NIA and the University of Pennsylvania in 2012 as a designated national data repository for human genetics research on Alzheimer's Disease and related dementia (ADRD). NIAGADS was established with 3 missions in mind:Curate, update, and disseminate high-quality data for ADRD genetic and genomic researchDevelop secure informatics infrastructure for data analysis, management, and disseminationSupport AD genetics data production and analysis activitiesLaunched in 2018, the NIAGADS DSS is a key data resource made up of high-quality data collection for ADRD genetic/genomic research, including whole genome and exome sequence data from the Alzheimer's Disease Sequencing Project (ADSP) and other genotype/phenotype data. The NIAGADS DSS (https://dss.niagads.org/) is developed and maintained by data scientists at NIAGADS and applies all data standards required by the NIH for a controlled access data repository. Open access data is made available, when possible (in alignments with submitting institutional IRB guidance on appropriate sharing), through the NIAGADS Open Access Platform. Details about open access resources NIAGADS offers can be found here: https://www.niagads.org/open-access/. ]]>