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Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

NIAID Data Ecosystem2026-05-01 收录

胶质瘤细胞生物学

神经肿瘤靶向治疗

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184698 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-09-08

胶质瘤细胞生物学

RNA表观转录组学

The most aggressive form of astrocytoma is glioblastoma multiforme (GBM) and it has a worse prognosis with less than a 14-months average survival after diagnosis. Though cancer stem cells are of small

NIAID Data Ecosystem100

Selectively targeting bromodomain and extraterminal proteins for degradation as a novel anti-glioblastoma strategy [ChIP-seq]

神经肿瘤靶向治疗

表观遗传调控

Purpose: Characterization of mechanism and vulnerability of BET protein dependency in GBM cells. Methods: ChIP-seq and RNA-seq were performed on GBM cells at different time points following treatment

NIAID Data Ecosystem50

Table 1 from Combining Brigatinib with mTOR Inhibition to Effectively Treat NF2-SWN–Associated and Sporadic NF2-Deficient Meningiomas

神经肿瘤靶向治疗

临床前药效评价

The relative response of AG-NF2-Luc2 tumor xenografts in mice prior to and after treatment with vehicle, brigatinib, INK128, or brigatinib + INK128.

Figshare2026-01-27 更新40

Supplementary Table S2 from Response Rate and Molecular Correlates to Encorafenib and Binimetinib in BRAF-V600E Mutant High-Grade Glioma

神经肿瘤靶向治疗

肿瘤分子标志物

Supplementary Table S2: Patient features.

Figshare2024-05-15 更新60

Combined inhibition of TOP1 and PARP: a synergistic therapeutic strategy for PTEN-deficient glioblastoma. Combined inhibition of TOP1 and PARP: a synergistic therapeutic strategy for PTEN-deficient glioblastoma

神经肿瘤靶向治疗

DNA损伤修复

Deletions or loss-of-function mutations in phosphatase and tensin homolog (PTEN) are common in glioblastoma (GBM) and have been associated with defective DNA damage repair. Here we investigated whethe

NIAID Data Ecosystem50

Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

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