Intestinal IKKa is required for tumor initiation in APC mutant mice
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We have generated a mouse model for tumor initiation carrying a mutation in APC and lacking IKKα in intestinal epithelial cells. IKKα-deficient intestinal cells primarily failed to generate adenomas, and the few adenomas arising in this background displayed a significant reduction in cell proliferation. Using an in vitro model for intestinal tumoroids (derived from adenoma initiating cells), we have performed RNA sequencing of wild type and IKKα-deficient intestinal tumoroids. This has demonstrated that epithelial IKKα controls transcription of stem cell-related genes and genes associated with proliferation and apoptosis.
提供机构：
Hospital del Mar
创建时间：
2022-02-20
