Structural Equation Model Files for Genetic Association Study of Dementia

Using genomic structural equation modeling, we integrated GWAS data from six large-scale dementia studies—the first such integration—to construct a unified “dementia genetic factor,” demonstrating that diverse dementia subtypes share a core genetic architecture. This innovative approach not only reveals cross-disorder genetic commonalities but, through its enhanced statistical power, provides critical insights into the shared etiology of dementia.