OGG1

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

本基因编码负责切除8-氧鸟嘌呤（一种由暴露于活性氧引起的致突变性碱基副产物）的酶。该酶的作用包括链裂解的裂解酶活性。该基因C端区域的选择性剪接将剪接变异体分为两大类，即1型和2型，取决于序列的最后一个外显子。1型选择性剪接变异体以第7外显子结尾，而2型以第8外显子结尾。所有变异体均共享一个共同的前端区域，其中包含一个对线粒体定位至关重要的线粒体靶向信号。已描述了该基因的许多选择性剪接变异体，但尚未确定每个变异体的全长性质。[由RefSeq提供，2008年8月]