Muta-mycosynthesis of Naphthalene Analogs
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https://figshare.com/articles/dataset/Muta_mycosynthesis_of_Naphthalene_Analogs/2184400
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资源简介：
A mutasynthetic strategy is introduced
for the mycosynthesis of
naphthalene-based molecules (mutadalesols A–F) with directed
substitution patterns and new frameworks by generating and using the ΔpksTL mutant strain of Daldinia eschscholzii. (±)-Mutadalesol A and its (+)-enantiomer are cytotoxic, and
its (−)-enantiomer inhibits Toll-like receptor 5 (TLR5). The
in-culture reactability of fungal oligoketide intermediates with 5-aminonaphthalen-1-ol
(ANL) is demonstrated, shedding light on bioorthogonal accesses to
unnatural molecule libraries valuable in drug discovery pipelines.
创建时间：
2016-02-14
