Materials S1 - Network Identification of Hormonal Regulation

Mathematical Appendix and Figures S1 and S2. Figure S1. The after treatment relations between ACTH, TSH, prolactin, and cortisol are shown here in more detail. ACTH-cortisol is clearly connected. The TSH-prolactin relation is more modest but still significant. The relation ACTH-TSH is significant, but shows a wide optimum, interestingly Cortisol-TSH shows a similarly wide optimum which is shifted to the right. ACTH-Prolactin shows a narrow optimum while cortisol-prolactin is again wider and shifted to the right. Figure S2. The lean control relations between ACTH, TSH, prolactin, and cortisol are shown here in more detail. ACTH-cortisol is clearly connected. The TSH-prolactin relation is more modest but still significant. The relation ACTH-TSH is significant, but shows a wide optimum, interestingly Cortisol-TSH shows a similarly wide optimum which is shifted to the right. ACTH-Prolactin shows a narrow optimum while cortisol-prolactin is again wider and shifted to the right. (PDF)