Exploring the bioactive properties of fucoidan from Sugar kelp to modulate the immune response and gut microbiota of Atlantic salmon

Long chain sulfated polysaccharides such as fucoidans are promising feed additives to improve animal health and welfare. Thus, our study evaluated the bioactive properties of a fucoidan-enriched fraction from sugar kelp (Saccharina lattissima) on the intestinal transcriptome of pre-smolts Atlantic salmon (Salmo salar) fed with novel functional aquafeeds for 5 weeks in freshwater. Overall design: Following a 5-week feeding experiment with Atlantic salmon (Salmo salar) pre-smolts fed supplemented diets containing fucoidan from Saccharina lattissima, intestinal samples were collected for transcriptomic analysis by RNA sequencing to explore the potential immunomodulatory properties of these compounds in fish.