ADORA2B:Ade-Rib:GsGTP dissociates

The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).

G-蛋白信号传导的经典观点认为，G-蛋白的α亚基会从β:γ二聚体中解离。随后，激活的Gα(s)与β:γ二聚体分别参与独立的信号级联反应。尽管G蛋白的解离作用曾受到质疑（例如，Bassi等，1996年），但近期在体内的实验研究表明，解离现象确实存在，尽管可能并未完全发生（Lambert，2008年）。