Coordinated directionality recovers monolayer closure behavior from single cell data.

Summary table depicting simulation results using the calibrated model (CM) to predict how PIEZO1 affects normalized wound closure and normalized edge length with altered adhesion and coordinated directionality parameters. A “+” indicates a parameter set has a predicted increase upon an experimental measure while a “−” indicates a predicted decrease. Double signs (+ + /−−) represent a stronger observed effect on the simulated measure than single signs (+ /−). Red font and cross mark indicate that model predictions calibrated by the “Single Cell Migration” dataset do not match experimental trends (Table 1), while a check mark ✔indicates that model predictions are consistent with experimental results. See also Fig 3, S7 and S8 Figs.