kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer

Kininogen (high molecular weight kininogen; HK) associates with C1q binding protein on the cell surface in a reaction dependent on Zn++ (Joseph et al. 1996). In the body, the Zn++ needed to drive this reaction may be provided locally by Zn++ release from activated platelets (Mahdi et al. 2002). The C1q binding protein is inferred to form tetramers based on the properties of purified recombinant protein in vitro (Ghebrehiwet et al. 1994); the stoichiometry of the cell surface complex has not been determined directly.

激肽原（高分子量激肽原；HK）与细胞表面上的C1q结合蛋白发生反应，该反应依赖于Zn++（Joseph等人，1996年）。在体内，驱动此反应所需的Zn++可能由活化血小板释放的Zn++在局部提供（Mahdi等人，2002年）。根据体外纯化重组蛋白的性质，推断C1q结合蛋白形成四聚体；细胞表面复合物的化学计量比尚未直接确定（Ghebrehiwet等人，1994年）。