Metabolic and Pharmacokinetic Profiling of an Exogenous Ketone Ester by Background SGLT2 Inhibitor Therapy in Heart Failure with Reduced Ejection Fraction: A Phase I Clinical Trial
收藏DataCite Commons2026-02-28 更新2026-05-04 收录
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资源简介：
Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ejection fraction participants, stratified by background SGLT2i, the authors detailed pharmacokinetic parameters, noting rapid ketosis and short half-life.
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OSF
创建时间：
2025-10-03
