Generation of Syngeneic Orthotopic DMG Murine Models
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP498608
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资源简介：
Diffuse Midline Glioma (DMG) syngeneic orthotopic murine mouse models were used as high fidelity model of human DMG tumors as they recapitulate the heterogeneity, cell states and OncoTarget/OncoTreat drug predictions of human DMG tumors. Overall design: Single-cells were isolated and sequenced from B6(Cg)-Tyrc-2J/J (B6) mice. An intracranial injection with 100,000 DIPG4423 cells was performed and tumor was isolated 3 weeks post-injection for single cell. Additionally, single cells were also isolated from normal brainstem (no tumor) of the same model
创建时间：
2025-12-23
