Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4]nonane-1,6-diones
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https://figshare.com/articles/dataset/Organocatalytic_Asymmetric_Tandem_Nazarov_Cyclization_Semipinacol_Rearrangement_Rapid_Construction_of_Chiral_Spiro_4_4_nonane_1_6_diones/2203723
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资源简介：
A novel
organocatalytic asymmetric tandem Nazarov cyclization/semipinacol
rearrangement reaction using “unactivated” substrates
has been developed, generating a series of chiral spiro[4.4]nonane-1,6-diones
in up to 96% yield and 97% enantiomeric excess. Significantly, it
is the first direct example for asymmetric synthesis of cyclopentanones
with four stereocenters using Nazarov cyclization. DFT calculations
have been applied to understand the reaction mechanism, stereochemistry,
and substituent effects.
创建时间：
2015-07-08
