Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-075
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
下载链接：
https://pdbj.org/mine/summary/7mr7
下载链接
链接失效反馈官方服务：
资源简介：
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-075 Descriptor: 1,2-ETHANEDIOL, 4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluoro-N-[1-(14-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]phenyl}-14-oxo-4,7,10-trioxa-13-azatetradecanan-1-oyl)piperidin-4-yl]benzamide, Bromodomain-containing protein 4 Authors: Chan, A, Schonbrunn, E. Deposit date: 2021-05-07 Release date: 2022-05-11 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
创建时间：
2021-05-07
