Crystal structure of HPK1 T165E/S171E in complex with pyrazine carboxamide inhibitor

Crystal structure of HPK1 T165E/S171E in complex with pyrazine carboxamide inhibitor Descriptor: 1,2-ETHANEDIOL, 3-[(1,3-dimethylpyrazol-4-yl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, Mitogen-activated protein kinase kinase kinase kinase 1 Authors: Schimpl, M. Deposit date: 2025-04-08 Release date: 2025-05-28 Last modified: 2025-09-03 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors. Rsc Med Chem, 16, 2025