Data_Sheet_1_Investigation of the Association Between History of Learning Disabilities and Primary Progressive Aphasia in Brazilian Portuguese Speakers.pdf

Primary Progressive Aphasia (PPA) is a neurological syndrome characterized by impaired language due to neurodegeneration. It is subdivided into three variants: semantic, agrammatic or nonfluent, and logopenic. Pieces of evidence have suggested that learning disabilities in childhood, such as dyslexia, might be susceptibility factors in the occurrence of PPA in adulthood. The objective of this study was to verify the existence of the relationship between PPA and the history of learning disabilities of patients and their children, compared to a control group of individuals with Alzheimer's disease (AD). A questionnaire was applied to investigate the presence of indicators of learning disabilities and difficulties in individuals with PPA and AD and their children. Twenty subjects with PPA and 16 with AD participated in the study. Our findings are presented and discussed in light of the current scientific evidence and the social, educational, and economic Brazilian scenario. Despite the challenges of doing research with individuals with PPA in Brazil, we present the first evidence about the investigation of association between the history of learning disabilities and difficulties and PPA in native Brazilian Portuguese speakers.

原发性进行性失语症（PPA）是一种由神经退行性病变引起的语言功能障碍的神经综合征。该症候群可分为三种亚型：语义型、非流畅型或无语法型以及开放型。现有证据表明，儿童时期的学习障碍，如阅读障碍，可能是成年后PPA发病的易感因素。本研究旨在验证PPA与患者及其子女的学习障碍病史之间的关系，并将其与阿尔茨海默病（AD）患者组成对照组进行比较。研究采用问卷调查法，以探究PPA和AD患者及其子女是否存在学习障碍和困难的指标。本实验共纳入PPA患者20名，AD患者16名。本研究结果在当前科学证据的基础上，结合巴西的社会、教育和经济背景进行分析和讨论。尽管在巴西对PPA患者进行研究面临诸多挑战，我们仍首次提供了关于学习障碍和困难病史与PPA之间关联的巴西葡萄牙语母语者的研究证据。