GEMiCCL

Cancer cell lines are essential components for biomedical research. However, proper choice of cell lines for experimental purposes is often difficult because genotype and/or expression data are missing or scattered in diverse resources. GEMiCCL (Gene Expression and Mutations in Cancer Cell Lines) is an online database of human cancer cell lines that provides genotype and expression information. The mutation, gene expression, and copy number variation (CNV) data were collected from three representative databases on cell lines – CCLE (Cancer Cell Line Encyclopedia), COSMIC (Catalogue of Somatic Mutations in Cancer), and NCI60. We re-processed the entire gene expression and SNP chip data and removed the batch effects due to different microarray platforms using the ComBat software.