GEMiCCL

Cancer cell lines are essential components for biomedical research. However, proper choice of cell lines for experimental purposes is often difficult because genotype and/or expression data are missing or scattered in diverse resources. GEMiCCL (Gene Expression and Mutations in Cancer Cell Lines) is an online database of human cancer cell lines that provides genotype and expression information. The mutation, gene expression, and copy number variation (CNV) data were collected from three representative databases on cell lines – CCLE (Cancer Cell Line Encyclopedia), COSMIC (Catalogue of Somatic Mutations in Cancer), and NCI60. We re-processed the entire gene expression and SNP chip data and removed the batch effects due to different microarray platforms using the ComBat software.癌症细胞系（Cancer cell lines）是生物医学研究的核心组成部分。然而，为实验研究合理选择适配的细胞系往往颇具难度，这是因为相关基因型与/或表达数据存在缺失，且分散于各类异构数据源中。GEMiCCL（Gene Expression and Mutations in Cancer Cell Lines）是一款面向人类癌症细胞系的在线数据库，可提供基因型与基因表达相关信息。该数据库的突变、基因表达以及拷贝数变异（Copy Number Variation, CNV）数据均采集自三类代表性细胞系数据库——CCLE（Cancer Cell Line Encyclopedia，癌症细胞系百科全书）、COSMIC（Catalogue of Somatic Mutations in Cancer，癌症体细胞突变目录）以及NCI60。本研究团队对全部基因表达数据与单核苷酸多态性（Single Nucleotide Polymorphism, SNP）芯片数据进行了重新处理，并借助ComBat软件消除了因不同微阵列平台所导致的批次效应。

搜集汇总

背景与挑战

背景概述

GEMiCCL是一个专注于人类癌症细胞线的在线数据库，整合了基因表达、突变和拷贝数变异（CNV）数据，来源于CCLE、COSMIC和NCI60等权威资源，并经过数据重处理以消除平台批次效应。该数据库覆盖1406个细胞线、185种癌症类型和29种组织，提供标准化的细胞线信息和用户友好的交互界面，支持复杂查询和可视化功能，旨在辅助生物医学研究中细胞线的选择和数据分析。