RNA sequencing study using Prox1-eGFP mice to investigate the role of lymphatic vasculature in chronic cardiac dysfunction

The goal of the study is to examine the transcriptional changes in different cell populations isolated from heart and diaphragm in angiotensin II infusion-induced cardiac dysfunction and with a lymphangiogenic therapy (VEGFCc156s) Prox1-eGFP mice were treated with BSA, angiotensin II in BSA or angiotensin II and VEGFCc156s for 5-6 weeks and used for the isolation of different cell populations from heart and diaphragm. The transcriptional profile of isolated cell populations was examined using RNA-Seq.