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Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982

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Protein Data Bank Japan2025-06-25 更新2026-03-28 收录
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Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982 Descriptor: 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Qiao, A.N, Wu, S, Ye, S. Deposit date: 2021-12-20 Release date: 2022-12-21 Last modified: 2025-06-25 Method: ELECTRON MICROSCOPY (2.33 Å) Cite: Activation and signaling mechanism revealed by GPR119-G s complex structures. Nat Commun, 13, 2022
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2021-12-20
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