C. elegans gene expression in response to Salmonella enterica infection and recovery by Tetracycline treatment
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(Part 1) Gene expression profiles of C. elegans in response to a 120 hour S. enterica infection. Synchronized larval stage 1 (L1) animals were exposed to S. enterica SL1344 for 36, 72, 96, or 120 hours. As an uninfected control, synchronized L1 animals were exposed to E. coli OP50 for 36 hours. (Part 2) Gene expression profiles of C. elegans in response to Tetracycline-mediated recovery from 72 hour and 96 hour S. enterica infections. Synchronized L1 animals were exposed to S. enterica SL1344 for 72 hours and then shifted to E. coli HT115 plus Tetracycline plates for 24 hours to resolve the infection. Synchronized L1 animals were exposed to S. enterica SL1344 for 96 hours and then shifted to E. coli HT115 plus Tetracycline plates for 24 hours to resolve the infection.
(第一部分) 秀丽隐杆线虫(Caenorhabditis elegans, C. elegans)应对120小时鼠伤寒沙门氏菌(Salmonella enterica, S. enterica)感染的基因表达谱数据集:将同步化的第一龄幼虫(L1)暴露于鼠伤寒沙门氏菌SL1344菌株中,分别培养36、72、96或120小时;未感染对照组则将同步化L1幼虫暴露于大肠杆菌(E. coli)OP50菌株中培养36小时。 (第二部分) 秀丽隐杆线虫经四环素(Tetracycline)介导的72小时及96小时鼠伤寒沙门氏菌感染后恢复过程的基因表达谱数据集:将同步化L1幼虫暴露于鼠伤寒沙门氏菌SL1344菌株中培养72小时,随后转移至添加四环素的大肠杆菌HT115菌株平板上培养24小时以清除感染;将同步化L1幼虫暴露于鼠伤寒沙门氏菌SL1344菌株中培养96小时,随后转移至添加四环素的大肠杆菌HT115菌株平板上培养24小时以清除感染。



