VCAM1 binds Integrin alpha4beta1

Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. Integrin alphaLbeta2 (LFA-1) interacts with Intercellular adhesion molecule (ICAM)1-5, which are typically expressed on other immune system cells. ICAM4 and 5 are known to be expressed on telencepahlic neurons.

VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.

整合素在介导淋巴细胞与多种表面的粘附中发挥着核心作用。整合素αLβ2（LFA-1）与细胞间粘附分子（ICAM）1-5相互作用，这些分子通常表达在其他免疫细胞上。已知ICAM4和5在颞叶神经元上表达。VCAM-1通过晚期抗原-4（VLA-4）调节淋巴细胞与活化内皮细胞的粘附。为了在循环模式下发挥作用，白细胞以低配体结合能力表达LFA-1和VLA-4。当白细胞达到炎症部位时，这些整合素被切换到高结合状态，以引导包括跨细胞迁移、系泊、滚动、停止、粘附和形态变化在内的复杂过程。LFA-1和VLA-4之间的信号级联可能发生互信，以相互影响结合亲和力。