Increased antigenicity of NURF-depleted tumors enhances CD8 T cell-mediated antitumor immunity

Depleting the NURF chromatin remodeling complex results in enhanced antitumor immunity using mouse tumor models syngenic to two strain backgrounds. Selective depletion of immune cells from tumor-bearing mice discovers that both CD8+ and CD4+ cells are necessary for enhanced antitumor immunity to NURF-depleted cells. Our results suggest that NURF-depleted cells have significant differences in antigenicity compared to control cells. Cloning, functional and molecular assays of CD8 T cells were performed to identify clones with enhanced activity to NURF-depleted tumor cells in NSG mice compared to control tumors.