Data_Sheet_1_Accuracy Improvement of In-line Near-Infrared Spectroscopic Moisture Monitoring in a Fluidized Bed Drying Process.PDF

An exploratory analysis of a large representative dataset obtained in a fluidized bed drying process of a pharmaceutical powder has revealed a significant correlation of spectral intensity with granulate humidity in the whole studied range of 1091.8–2106.5 nm. This effect was explained by the dependence of powder refractive properties, and hence light penetration depth, on the water content. The phenomenon exhibited a close spectral similarity to the well-known stochastic variation of spectral intensities caused by the process turbulence (the so-called “scatter effect”). Therefore, any traditional scatter-corrective preprocessing incidentally eliminates moisture-correlated variance from the data. To preserve this additional information for a more precise moisture calibration, a time-domain averaging of spectral variables has been suggested. Its application resulted in a distinct improvement of prediction accuracy, as compared to the scatter-corrected data. Further improvement of the model performance was achieved by the application of a dynamic focusing strategy when adjusting the model to a drying process stage. Probe fouling was shown to have a minor effect on prediction accuracy. The study resulted in a considerable reduction of the root-mean-square error of in-line moisture monitoring to 0.1%, which is close to the reference method's reproducibility and significantly better than previously reported results.