Maintenance of CTCF and transcription factor-mediated interactions from gametes to the early mouse embryo
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2019-05-30
相关数据集
The WNT-dependent gating of MYC requires non-canonical functions of a distal CTCF binding site. The WNT-dependent gating of MYC requires non-canonical functions of a distal CTCF binding site
Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer (OSE)-mediated gating of MYC to the nuclear pore. This process enables MYC transcripts to esc
NIAID Data Ecosystem80
An ectopic CTCF binding element disturbs Vδ usage at the mouse Tcra-Tcrd locus by regulating contact between Vδ and Dδ gene segments
An ectopic CTCF binding element disturbs Vδ usage at the mouse Tcra-Tcrd locus by regulating contact between Vδ and Dδ gene segments
ChEBI2016-09-02 更新40
Global analysis of expression upon RNA Pol I inhibition (iPol I) in ESCs. Global analysis of expression upon RNA Pol I inhibition (iPol I) in ESCs
Immediately following fertilisation, the genomes of mammalian embryos undergo extensive reprogramming to generate a totipotent zygote with the capacity to form the entire developing organism and assoc
NIAID Data Ecosystem30
Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping. Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping
In human cells, CTCF’s role in genomic organization and global transcription regulation is less clearly defined due to the lack of available tools to efficiently deplete CTCF. Here, we used an auxin-i
NIAID Data Ecosystem60
OBOX regulates murine zygotic genome activation and early development. OBOX regulates murine zygotic genome activation and early development
Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-zygotic transition. However, the identity of transcription factors (TFs) that underlie mammalian ZGA in vivo re
NIAID Data Ecosystem40
