Human DNA

Primary central nervous system (CNS) lymphoma of the meninges is a rare tumor that originates in the meninges, and does not show parenchymal or systemic spread. CNS involvement by natural killer (NK)/T-cell lymphoma accounts for only 2% of all extranodal NK/T-cell lymphomas, and primary NK/T-cell lymphoma of the meninges is even rarer. We report a case of primary NK/T-cell lymphoma in a 55-year-old Chinese man. The patient presented with intermittent dizziness and headaches for the past 1 month. Magnetic resonance imaging of the head revealed no obvious abnormalities. However, during cerebrospinal fluid (CSF) cytological analysis, Wright-Giemsa staining revealed numerous atypical lymphocytes and lymphoma cells. Flow cytometry of the CSF was performed as an auxiliary method to establish a diagnosis of NK/T-cell lymphoma. To further demonstrate the disease, we do the genetic test of CSF.