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MicroRNA alterations in a mouse model of prion disease

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146013
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MicroRNA alterations were investigated in a Tg501 mouse model of prion disases that express the goat prion protein (PRNP). Age-matched Tg501 mice without inoculation (controls) and intracranially inoculated with caprine scrapie strain were compared in presymptomatic and symptomatic stages. Small RNA profiles from cervical spinal cord of prion-inoculated (n=11) and non-inoculated (n=13), age-matched Tg501 mice were generated at symptomatic (n=12) and presymptomatic (n=12) stage using HiSeq v4 chemistry on Illumina HiSeq 2500.
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2020-09-16
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