A list of SNP pairs identified by SNP-SNP interaction tests in GWAS.

Interactive SNP pairs are listed in their order of significance. For each SNP of an interactive pair, chromosome (CHR), RS number (RS), physical position (PP), gene information (GI), genotyping call rate (GCR(%)) and minor allele frequency (MAF) are shown. Finally, the −log10(p) value from three interaction tests is shown: (1) the difference test of odds ratio (ORT), (2) an interaction test of the CLR-NOMINAL analysis [model: logit{Prob(Y = YOH|I11,I12,I21,I22,I11×I21,I11×I22,I12×I21,I12×I22)} = a0+a11×I11+a12×I12+a21×I21+a22×I22+b1×I11×I21+b2×I11×I22+b3×I12×I21+b4×I12×I22] and (3) an interaction test of the CLR-ORDINAL analysis [model: logit{Prob(Y = YOH|X1, X2, X1×X2)} = a0+a1×X1+a2×X2+a3×X1×X2], where Y is YOH status, Iij is an indicator of the three genotypes (j = 1, 2) of SNP i (i = 1, 2) and Xi denotes the number of reference alleles of SNP i (i = 1, 2).