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Human Placental Transcriptome and fetal sex differences in SPTB

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DataCite Commons2022-12-21 更新2025-04-16 收录
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https://www.immport.org/shared/study/SDY1899
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The study performed a RNA-seq analysis in male and female placentas from 16 women with SPTB (<36 weeks gestation) compared to 16 normal pregnancies (≥38 weeks gestation) to assess the alterations in the gene expression profiles. The transcriptome was integrated with published human placental metabolome to assess the interactions of altered genes and metabolites. Collectively, significant and biologically relevant alterations in the transcriptome were identified in SPTB placentas with fetal sex disparities. Altered energy metabolism, mitochondrial function, inflammation, and detoxification may underly the mechanisms of placental dysfunction in SPTB
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ImmPort
创建时间:
2022-01-17
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