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NHC-Catalyzed Spiro Bis-Indane Formation via Domino Stetter−Aldol−Michael and Stetter−Aldol−Aldol Reactions

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NIAID Data Ecosystem2026-03-06 收录
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Two novel domino NHC-catalyzed spirocyclizations are described herein, enabling the rapid construction of three new carbon−carbon bonds and a quaternary center with high diastereoselectivity. A variety of spiro bis-indane structures are assembled in a single step from simple o-phthaldialdehyde derivatives.

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2010-12-17
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