Homo sapiens Raw sequence reads. Homo sapiens

To investigate how the loss of PTMs at specific sites of nucleolin affects gene expression, we performed RNA sequencing (RNA-seq) analysis of the nuclear extracts of Huh7 cells overexpressing WT, S67A, K398R, and K646R mutant nucleolin. The overexpression of NCL-WT resulted in the significant differential expression of 6,696 genes, 3,982 and 2,714 of which were upregulated and downregulated, respectively.