Deconvolution of the mechanisms of T cell drug response in multiple myeloma induction therapy

In this study, we characterize the effect of bortezomib, lenalidomide, and dexamethasone on T cells, with the help of high-quality datasets generated using the trimodal single-cell genomics method TEA-seq, which captures mRNA transcripts, cell surface epitopes, and chromatin accessibility. We describe alterations to T cell receptor signaling pathways, metabolism, and cell signaling that have important implications for T cell function, survival, and localization. Multimodal characterization of bortezomib, lenalidomide, dexamethasone, and DMSO-only control treaments on healthy T cells, studied at three different treatment time-points (0h, 24h, 72h). **RAW data will be submitted to dbGAP**