coculture SAEC and HMVEC exposed to MWCNT. coculture SAEC and HMVEC exposed to MWCNT

This study compared global multi-walled carbon nanotube (MWCNT)-induced miRNA expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with miRNA expression from mouse lungs exposed to MWCNT. The concordant miRNA in human cell lines, mouse lung tissues and blood will be potential biomarkers for occupational and medical surveillance. Overall design: Global miRNA expression profiles in monoculture and coculture HMVEC and SAEC cell lines are compared with the miRNA profiles in mouse lung tissues and blood samples exposed to MWCNT. The miRNAs with concordant MWCNT-induced reguation are identified.