EASE analysis.

Using EASE (http://david.abcc.ncifcrf.gov/), genes with increased expression in IAD are significantly overrepresented in gene ontology biological process categories that are important for synaptic function such as synaptic transmission, neuronal cell recognition and vesicle-mediated transmission. Genes with decreased expression in IAD are significantly overrepresented in categories relevant to chromatin modification, cell-cycle and carbohydrate metabolism. EASE score equals the upper bound of the distribution of Jacknife Fisher exact probabilities given the List Hits, List Total, Population Hits and Population Total. Upregulated genes (303) and downregulated genes (157) were separately analyzed with EASE.