Supplemental data for Conformational dynamics in the membrane penetration of bispecific targeted degrader therapeutics, Inganäs et al.

Supplemental data for Conformational dynamics in the membrane penetration of bispecific targeted degrader therapeutics, Inganäs et al.

Molecular formula strings.xlsx contains SMILES format structures and separation into E3 ligase ligand, linker and POI ligand substructures for all 3589 analyzed PROTACs, and their original literature references. 2D Key experimental details.xlsx contains molecular properties calculated from 2D structures (used in Table 1). 3D Key experimental details.xlsx contains molecular properties calculated from 3D structures (Figure 2). Membrane simulation details.xlsx contains details on the PROTAC–membrane simulations (Figures 3-5), and Experimental key details.xlsx contains details on the experimental measurements of PROTAC–cell membrane interactions (Figures 3 and 5).